Genetic influences on sulcal patterns of the brain

Joshi, S. H., Joshi, A. A., Gutman, B., Toga, A. W., McMahon, K., de Zubicaray, G., Martin, N., Wright, M. J., & Thompson, P. M. (2012) Genetic influences on sulcal patterns of the brain. In 2012 9th IEEE International Symposium on Biomedical Imaging : From Nano to Macro: Proceedings: May 2-5, 2012, Barcelona, Spain, IEEE, Barcelona, Spain, pp. 414-417.

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We present a shape-space approach for analyzing genetic influences on the shapes of the sulcal folding patterns on the cortex. Sulci are represented as continuously parameterized functions in a shape space, and shape differences between sulci are obtained via geodesics between them. The resulting statistical shape analysis framework is used not only to construct populations averages, but also used to compute meaningful correlations within and across groups of sulcal shapes. More importantly, we present a new algorithm that extends the traditional Euclidean estimate of the intra-class correlation to the geometric shape space, thereby allowing us to study heritability of sulcal shape traits for a population of 193 twin pairs. This new methodology reveals strong genetic influences on the sulcal geometry of the cortex.

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ID Code: 85796
Item Type: Conference Paper
Refereed: Yes
Keywords: brain imaging, genetics, heritability, shape analysis, sulcal curves
DOI: 10.1109/ISBI.2012.6235572
ISBN: 9781457718571
ISSN: 1945-7928
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 IEEE
Deposited On: 21 Oct 2015 05:05
Last Modified: 29 Oct 2015 03:55

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