Automatic clustering and population analysis of white matter tracts using maximum density paths

Prasad, G., Joshi, S. H., Jahanshad, N., Villalon-Reina, J., Aganj, I., Lenglet, C., Sapiro, G., McMahon, K. L., de Zubicaray, Greig I., Martin, N. G., Wright, M. J., Toga, A. W., & Thompson, P. M. (2014) Automatic clustering and population analysis of white matter tracts using maximum density paths. NeuroImage, 97, pp. 284-295.

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Abstract

We introduce a framework for population analysis of white matter tracts based on diffusion-weighted images of the brain. The framework enables extraction of fibers from high angular resolution diffusion images (HARDI); clustering of the fibers based partly on prior knowledge from an atlas; representation of the fiber bundles compactly using a path following points of highest density (maximum density path; MDP); and registration of these paths together using geodesic curve matching to find local correspondences across a population. We demonstrate our method on 4-Tesla HARDI scans from 565 young adults to compute localized statistics across 50 white matter tracts based on fractional anisotropy (FA). Experimental results show increased sensitivity in the determination of genetic influences on principal fiber tracts compared to the tract-based spatial statistics (TBSS) method. Our results show that the MDP representation reveals important parts of the white matter structure and considerably reduces the dimensionality over comparable fiber matching approaches.

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11 citations in Scopus
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10 citations in Web of Science®

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ID Code: 85820
Item Type: Journal Article
Refereed: Yes
Keywords: Atlas, Brain, Clustering, Connectivity, Curve registration, Dijkstra, Geodesic distance, HARDI, Hough, Longest path, Maximum density path, MRI, Shortest path, Tractography
DOI: 10.1016/j.neuroimage.2014.04.033
ISSN: 1095-9572
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier
Deposited On: 01 Sep 2015 01:34
Last Modified: 04 Sep 2015 01:46

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