Cognitive functioning in older twins: The Older Australian Twins Study

Sachdev, P. S., Lee, T., Lammel, A., Crawford, J., Trollor, J. N., Wright, M. J., Brodaty, H., Ames, D., Martin, N. G., Arasaratnam, C., Azar, P., Halliday, G., Harding, A., Kumfor, F., Lux, O., Menant, J., Nichles, A., Schofield, P., Walker, A., Wong, A., Zhang, J., Beeby, H., Eldrdge, A., Garden, N., Grace, M., Henders, A., McMahon, K., Park, D., Redfern, C., Tovanen, A., de Zubicaray, G., Delmar, G., Lemmon, C., Mangelsdorf, S., Cortes, N., & Walker, S. (2011) Cognitive functioning in older twins: The Older Australian Twins Study. Australasian Journal on Ageing, 30(SUPPL.), pp. 17-23.

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Abstract

Aim: To examine the concordance rates of common medical conditions and neurocognitive performance in monozygotic (MZ) and dizygotic (DZ) older twins. Methods: Twins aged ≥65 years and living in the three Eastern states of Australia were recruited through the Australian Twin Registry and underwent detailed neuropsychological and medical assessment. Results: Assessments were conducted on 113 MZ and 96 DZ twin pairs, with a mean age of 70.5 years. MZ twins were more concordant than DZ twins for hypertension and asthma. MZ twins had higher correlations than DZ twins on most neuropsychological tests, with the exception of some tests related to processing speed. The concordance rate for mild cognitive impairment or dementia was 76.2% in MZ twins and 42.9% in DZ twins, a non-significant difference. Conclusions: Except for some aspects of processing speed, most cognitive functions in older individuals show significant heritability. The heritability of neurocognitive disorders is, however, low.

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ID Code: 85828
Item Type: Journal Article
Refereed: Yes
Keywords: Ageing, Brain, Cognitive function, Mild cognitive impairment, Twin
DOI: 10.1111/j.1741-6612.2011.00534.x
ISSN: 1741-6612
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 The Authors
Deposited On: 01 Sep 2015 05:38
Last Modified: 17 Sep 2015 04:49

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