Direct mapping of hippocampal surfaces with intrinsic shape context

Shi, Y., Thompson, P. M., de Zubicaray, Greig I., Rose, S. E., Tu, Z., Dinov, I., & Toga, A. W. (2007) Direct mapping of hippocampal surfaces with intrinsic shape context. NeuroImage, 37(3), pp. 792-807.

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We propose in this paper a new method for the mapping of hippocampal (HC) surfaces to establish correspondences between points on HC surfaces and enable localized HC shape analysis. A novel geometric feature, the intrinsic shape context, is defined to capture the global characteristics of the HC shapes. Based on this intrinsic feature, an automatic algorithm is developed to detect a set of landmark curves that are stable across population. The direct map between a source and target HC surface is then solved as the minimizer of a harmonic energy function defined on the source surface with landmark constraints. For numerical solutions, we compute the map with the approach of solving partial differential equations on implicit surfaces. The direct mapping method has the following properties: (1) it has the advantage of being automatic; (2) it is invariant to the pose of HC shapes. In our experiments, we apply the direct mapping method to study temporal changes of HC asymmetry in Alzheimer's disease (AD) using HC surfaces from 12 AD patients and 14 normal controls. Our results show that the AD group has a different trend in temporal changes of HC asymmetry than the group of normal controls. We also demonstrate the flexibility of the direct mapping method by applying it to construct spherical maps of HC surfaces. Spherical harmonics (SPHARM) analysis is then applied and it confirms our results on temporal changes of HC asymmetry in AD.

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31 citations in Web of Science®

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ID Code: 85835
Item Type: Journal Article
Refereed: Yes
Keywords: Alzheimer's disease, Asymmetry, Direct mapping, Hippocampal surface, Implicit representation, Intrinsic shape context, Level set, Shape analysis, Temporal changes
DOI: 10.1016/j.neuroimage.2007.05.016
ISSN: 1095-9572
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Elsevier
Deposited On: 04 Sep 2015 01:08
Last Modified: 04 Sep 2015 01:08

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