A functional MRI study of the relationship between naming treatment outcomes and resting state functional connectivity in post-stroke aphasia

Van Hees, S., McMahon, K., Angwin, A., de Zubicaray, G., Read, S., & Copland, D. A. (2014) A functional MRI study of the relationship between naming treatment outcomes and resting state functional connectivity in post-stroke aphasia. Human Brain Mapping, 35(8), pp. 3919-3931.

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Background: The majority of studies investigating the neural mechanisms underlying treatment in people with aphasia have examined task-based brain activity. However, the use of resting-state fMRI may provide another method of examining the brain mechanisms responsible for treatment-induced recovery, and allows for investigation into connectivity within complex functional networks Methods: Eight people with aphasia underwent 12 treatment sessions that aimed to improve object naming. Half the sessions employed a phonologically-based task, and half the sessions employed a semantic-based task, with resting-state fMRI conducted pre- and post-treatment. Brain regions in which the amplitude of low frequency fluctuations (ALFF) correlated with treatment outcomes were used as seeds for functional connectivity (FC) analysis. FC maps were compared from pre- to post-treatment, as well as with a group of 12 healthy older controls Results: Pre-treatment ALFF in the right middle temporal gyrus (MTG) correlated with greater outcomes for the phonological treatment, with a shift to the left MTG and supramarginal gyrus, as well as the right inferior frontal gyrus, post-treatment. When compared to controls, participants with aphasia showed both normalization and up-regulation of connectivity within language networks post-treatment, predominantly in the left hemisphere Conclusions: The results provide preliminary evidence that treatments for naming impairments affect the FC of language networks, and may aid in understanding the neural mechanisms underlying the rehabilitation of language post-stroke.

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ID Code: 85848
Item Type: Journal Article
Refereed: Yes
Keywords: Anomia, Language network, Phonology, Rehabilitation, Semantics
DOI: 10.1002/hbm.22448
ISSN: 1097-0193
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Wiley Periodicals, Inc.
Deposited On: 28 Sep 2015 03:23
Last Modified: 30 Sep 2015 03:02

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