A reproducible method for automated extraction of brain volumes from 3D human head MR images

Wang, D., Galloway, G. J., De Zubicaray, G. I., Rose, S. E., Chalk, J. B., Doddrell, D. M., & Semple, J. (1998) A reproducible method for automated extraction of brain volumes from 3D human head MR images. Journal of Magnetic Resonance Imaging, 8(2), pp. 480-486.

View at publisher


An automated method for extracting brain volumes from three commonly acquired three-dimensional (3D) MR images (proton density, T1 weighted, and T2-weighted) of the human head is described. The procedure is divided into four levels: preprocessing, segmentation, scalp removal, and postprocessing. A user-provided reference point is the sole operator-dependent input required. The method's parameters were first optimized and then fixed and applied to 30 repeat data sets from 15 normal older adult subjects to investigate its reproducibility. Percent differences between total brain volumes (TBVs) for the subjects' repeated data sets ranged from .5% to 2.2%. We conclude that the method is both robust and reproducible and has the potential for wide application.

Impact and interest:

16 citations in Scopus
16 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 85854
Item Type: Journal Article
Refereed: Yes
Keywords: Automated extraction, MRI, Total brain volume estimation
DOI: 10.1002/jmri.1880080232
ISSN: 1522-2586
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 17 Jul 2015 07:09
Last Modified: 25 Jun 2017 06:01

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page