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Acute formoterol administration has no ergogenic effect in nonasthmatic athletes

Stewart, Ian B., LaBreche, Jane M., & McKenzie, Donald C. (2002) Acute formoterol administration has no ergogenic effect in nonasthmatic athletes. Medicine and Science in Sports and Exercise, 34(2), pp. 213-217.

Abstract

Purpose: To determine the effect of formoterol (formoterol fumarate dihydrate) on the aerobic and anaerobic capacities of highly trained athletes.

Methods: 10 male athletes (age = 26.2 +/- 0.9, O2max = 65.6 +/- 2.4 mL[middle dot]kg-1[middle dot]min-1) with minimal bronchial reactivity to aerosols (i.e., negative methacholine challenge test) completed three identical exercise sessions differing only by the medication administered. Formoterol (F) a long-acting [beta]2-agonist, presently not approved for international competition by the I.O.C. Medical committee, was compared with salbutamol (S), an accepted bronchodilator, and a placebo (P). Formoterol (12 [mu]g), salbutamol (400 [mu]g), or placebo was administered by a Turbuhaler, 10 min before exercise testing in a double-blind, randomized, three-way crossover design. Testing sessions included a Wingate anaerobic test followed 15 min later by an incremental cycle ergometer test to exhaustion.

Results: There were no significant differences between the groups in O2max (F = 66.5 +/- 2.7; S = 67.8 +/- 2.5; P = 67.5 +/- 2.1 mL[middle dot]kg-1[middle dot]min-1) or Wingate peak power (F = 885 +/- 40; S = 877 +/- 40; P = 885 +/- 44 W) values. During the maximal aerobic test, no differences were observed in maximum minute ventilation, respiratory exchange ratio, heart rate, or work between the three experimental conditions. Also, there were no differences in the Wingate anaerobic test variables, total work, or fatigue index.

Conclusion: Formoterol, administered in one aerosolized therapeutic dose, does not have an ergogenic effect in elite athletes without asthma.

Impact and interest:

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ID Code: 8625
Item Type: Journal Article
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author. Author contact details: i.stewart@qut.edu.au
Additional URLs:
Keywords: [beta]2, AGONIST, EXERCISE, ERGOGENIC AGENT
ISSN: 1530-0315
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Human Movement and Sports Science not elsewhere classified (110699)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 American College of Sports Medicine
Deposited On: 16 Jul 2007
Last Modified: 11 Aug 2011 02:04

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