The role of endogenous scabies mite complement inhibitors in the development of Streptococcus pyogenes skin infections

Christian, Lindsay Darryl (2015) The role of endogenous scabies mite complement inhibitors in the development of Streptococcus pyogenes skin infections. Masters by Research thesis, Queensland University of Technology.


This project expands upon the discovery that scabies mites produce protein molecules that interfere with the human complement cascade, disrupting a critical component of the early stages of the host immune response. This is believed to provide an optimal environment for the development of commonly associated secondary bacterial infections. The thesis investigated the effect of two distinct scabies mite proteins, namely SMS B4 and SMIPP-S I1, on the in vitro proliferation of Group A Streptococcus in whole human blood. Additionally, in vitro immunoassays were performed to determine if complement mediated opsonisation and phagocytosis were also disrupted.

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68 since deposited on 24 Sep 2015
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ID Code: 86523
Item Type: QUT Thesis (Masters by Research)
Supervisor: Hafner, Louise & Timms, Peter
Keywords: Scabies, Streptococcus pyogenes, secondary bacterial infection, complement, opsonisation, phagocytosis
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 24 Sep 2015 06:58
Last Modified: 25 Sep 2015 00:10

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