Roberts, Jason A., Taccone, Fabio Silvio, & Lipman, Jeffrey (2016) Understanding PK/PD. Intensive Care Medicine, 42(11), pp. 1797-1800.
Administrators only until November 2017 | Request a copy from author
Pharmacology is the science underpinning dosing, mechanisms of action and effectiveness of drugs. Central to pharmacology, are the studies of pharmacokinetics (PK) and pharmacodynamics (PD). On one hand, PK defines the time-course of drug concentrations in the body and incorporates the broad concepts of drug absorption, distribution, metabolism and elimination. On the other hand, PD describes the relationship between drug concentrations and pharmacological effects. In practice, PK is often referred as “what the body does to the drug” whilst PD as “what the drug does to the body”. Thus, PK/PD describes the relationship between drug dose and pharmacological effects with changes in drug concentrations leading to different pharmacological effects.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||pharmacokinetics, pharmacodynamics, drugs, dosing|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000) > Nursing not elsewhere classified (111099)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Nursing
|Copyright Owner:||Copyright 2015 Springer|
|Copyright Statement:||The final publication is available at Springer via http://dx.doi.org/10.1007/s00134-015-4032-6|
|Deposited On:||18 Aug 2015 00:16|
|Last Modified:||20 Oct 2016 23:46|
Repository Staff Only: item control page