Understanding PK/PD

Roberts, Jason A., Taccone, Fabio Silvio, & Lipman, Jeffrey (2016) Understanding PK/PD. Intensive Care Medicine, 42(11), pp. 1797-1800.

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Abstract

Pharmacology is the science underpinning dosing, mechanisms of action and effectiveness of drugs. Central to pharmacology, are the studies of pharmacokinetics (PK) and pharmacodynamics (PD). On one hand, PK defines the time-course of drug concentrations in the body and incorporates the broad concepts of drug absorption, distribution, metabolism and elimination. On the other hand, PD describes the relationship between drug concentrations and pharmacological effects. In practice, PK is often referred as “what the body does to the drug” whilst PD as “what the drug does to the body”. Thus, PK/PD describes the relationship between drug dose and pharmacological effects with changes in drug concentrations leading to different pharmacological effects.

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ID Code: 86586
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: pharmacokinetics, pharmacodynamics, drugs, dosing
DOI: 10.1007/s00134-015-4032-6
ISSN: 1432-1238
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000) > Nursing not elsewhere classified (111099)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Nursing
Copyright Owner: Copyright 2015 Springer
Copyright Statement: The final publication is available at Springer via http://dx.doi.org/10.1007/s00134-015-4032-6
Deposited On: 18 Aug 2015 00:16
Last Modified: 20 Oct 2016 23:46

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