QUT ePrints

Longitudinal study of MRS metabolites in Rasmussen's encephalitis

Wellard, R. Mark, Briellmann, Regula S., Wilson, Jennifer C., Kalnins, Renate M., Federico, Paolo, Anderson, Dianne P., Fabinyi, Gavin C. A., Harvey, A. Simon, Sceffer, Ingrid E., & Jackson, Graeme D. (2004) Longitudinal study of MRS metabolites in Rasmussen's encephalitis. Brain, 127(6), pp. 1302-1312.

View at publisher

Abstract

This study analyses the evolution of metabolite changes in an eight-year-old boy with focal Rasmussen’s encephalitis. Five MR-imaging examinations, including MR spectroscopy (MRS) were performed over 9 months. Following complex partial status, T2-weighted imaging showed transient dramatic signal increase in the left superior temporal gyrus and mesial temporal structures. Subsequent scans showed resolution of the swelling and signal normalization, with development of slight focal atrophy. MRS showed transient reduction in N-acetylaspartate, total creatine and trimethylamines. Later scans showed complete resolution of these metabolite abnormalities, followed by development of abnormal metabolite values. Lactate and glutamine/glutamate (Glx) were elevated after status. After surgery, ex-vivo high-field 1H and 31P MRS confirmed metabolite abnormalities (elevated choline and decreased aspartate, N-acetylaspartate, glutamate (1H) together with altered phospholipid ratios (31P). This suggested a more active disease process in the anterior region of the excised superior temporal gyrus. We conclude that even Rasmussen's encephalitis is a dynamic and active process of disease progression and seizure effects where neuronal injury and recovery of neuronal impairment can occur.

Impact and interest:

17 citations in Scopus
Search Google Scholar™
15 citations in Web of Science®

Citation countsare sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 8661
Item Type: Journal Article
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author. Author contact details: m.wellard@qut.edu.au
Keywords: chronic localized encephalitis, epilepsy, magnetic resonance spectroscopy, MRS
DOI: 10.1093/brain/awh157
ISSN: 0006-8950
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PAEDIATRICS AND REPRODUCTIVE MEDICINE (111400) > Paediatrics (111403)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Metabolism (060104)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry and Metabolomics not elsewhere classified (110199)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Analytical Biochemistry (060101)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Medical Biotechnology not elsewhere classified (100499)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PHYSIOLOGY (060600) > Animal Physiology - Biophysics (060601)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600) > Systems Physiology (111603)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Central Nervous System (110903)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Cellular Nervous System (110902)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Neurochemistry (060105)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Medical Biotechnology Diagnostics (incl. Biosensors) (100402)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurology and Neuromuscular Diseases (110904)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Oxford University Press
Deposited On: 17 Jul 2007
Last Modified: 29 Feb 2012 23:20

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page