Adverse effects of androgen-deprivation therapy in prostate cancer and their management

Rhee, Handoo, Gunter, Jennifer H., Heathcote, Peter, Ho, Ken, Stricker, Phillip, Corcoran, Niall M., & Nelson, Colleen C. (2015) Adverse effects of androgen-deprivation therapy in prostate cancer and their management. BJU International, 115(S5), pp. 3-13.

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Abstract

Objective

To provide an up-to-date summary of current literature on the management of adverse effects of androgen-deprivation therapy (ADT).

Patients and Methods

All relevant medical literature on men with prostate cancer treated with ADT from 2005 to 2014, and older relevant papers, were reviewed. Recent health advisory statements from the Australian government, societies and advocacy groups have been incorporated to the document.

Results

There are numerous adverse effects of ADT that require pro-active prevention and treatment. Ranging from cardiovascular disease, diabetes and osteoporosis, to depression, cognitive decline and sexual dysfunction, the range of adverse effects is wide. Baseline assessment, monitoring, prevention and consultation from a multidisciplinary team are important in minimising the harm from ADT.

Conclusions

This review provides a series of practical recommendations to assist with managing the adverse effects of ADT.

Impact and interest:

11 citations in Scopus
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11 citations in Web of Science®

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ID Code: 86620
Item Type: Journal Article
Refereed: Yes
Additional Information: Special Issue: Urological Society of Australia and New Zealand. The Urological Society of Australia and New Zealand and Wiley have published this supplement with no financial support
Keywords: androgen-deprivation therapy, prostate cancer, adverse effects
DOI: 10.1111/bju.12964
ISSN: 1464-4096
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Therapy (excl. Chemotherapy and Radiation Therapy) (111204)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Funding:
  • CCQ/1062939
Copyright Owner: © 2014 The Authors. BJU International © 2014 BJU International
Deposited On: 29 Oct 2015 01:50
Last Modified: 12 Sep 2016 23:40

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