Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

MacRae, Sheila L., Zhang, Quanwei, Lemetre, Christophe, Seim, Inge, Calder, Robert B., Hoeijmakers, Jan, Suh, Yousin, Gladyshev, Vadim N., Seluanov, Andrei, Gorbunova, Vera, Vijg, Jan, & Zhang, Zhengdong D. (2015) Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell, 14(2), pp. 288-291.

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Abstract

Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of CEBPG, a regulator of DNA repair, and TINF2, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long-lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.

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7 citations in Scopus
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5 citations in Web of Science®

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ID Code: 86624
Item Type: Journal Article
Refereed: Yes
Keywords: aging, gene duplication, genome maintenance, longevity, mutation rate
DOI: 10.1111/acel.12314
ISSN: 1474-9718
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > EVOLUTIONARY BIOLOGY (060300) > Phylogeny and Comparative Analysis (060309)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genomics (060408)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 The Authors
Copyright Statement: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Deposited On: 17 Aug 2015 05:20
Last Modified: 20 Oct 2015 00:37

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