Mathematical models for collective cell spreading

Treloar, Katrina K. (2015) Mathematical models for collective cell spreading. PhD by Publication, Queensland University of Technology.


Collective cell spreading is frequently observed in development, tissue repair and disease progression. Mathematical modelling used in conjunction with experimental investigation can provide key insights into the mechanisms driving the spread of cell populations. In this study, we investigated how experimental and modelling frameworks can be used to identify several key features underlying collective cell spreading. In particular, we were able to independently quantify the roles of cell motility and cell proliferation in a spreading cell population, and investigate how these roles are influenced by factors such as the initial cell density, type of cell population and the assay geometry.

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ID Code: 86960
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Simpson, Matthew & McCue, Scott
Keywords: Mathematical Model, Cell migration, Cell proliferation, Cell-to-cell adhesion, Circular barrier assay, Random walk model, in vitro, wound-healing, cancer, collective cell spreading
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 17 Feb 2016 04:29
Last Modified: 17 Feb 2016 04:29

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