Identification of genetic variants contributing to the migraine phenotype in different Australian populations

Rodriguez Acevedo, Astrid Jannet (2015) Identification of genetic variants contributing to the migraine phenotype in different Australian populations. PhD by Publication, Queensland University of Technology.

Abstract

This project aimed to identify novel genetic risk variants associated with migraine in the Norfolk Island population. Statistical analysis and bioinformatics approaches such as polygenic modeling and gene clustering methods were carried out to explore genotypic and expression data from high-throughput techniques. This project had a particular focus on hormonal genes and other genetic variants and identified a modest effect size on the migraine phenotype.

Impact and interest:

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ID Code: 87082
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Griffiths, Lyn & Lea, Rodney
Keywords: Migraine, Menstrual Migraine, Norfolk Island Population, ESR1, TNF, Genetic Risk Score, Clustering Analysis, Association studies, eQTL analysis
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 09 Oct 2015 05:06
Last Modified: 21 Mar 2016 05:27

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