Case-control study of ADARB1 and ADARB2 gene variants in migraine

Gasparini, Claudia F, Sutherland, Heidi G, Maher, Bridget, Rodriguez-Acevedo, Astrid J, Khlifi, Elhame, Haupt, Larisa M, & Griffiths, Lyn R (2015) Case-control study of ADARB1 and ADARB2 gene variants in migraine. The Journal of Headache and Pain, 16, pp. 31-38.

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Abstract

Background:

Migraine causes crippling attacks of severe head pain along with associated nausea, vomiting, photophobia and/or phonophobia. The aim of this study was to investigate single nucleotide polymorphisms (SNPs) in the adenosine deaminase, RNA-specific, B1 (ADARB1)and adenosine deaminase, RNA specific, B2 (ADARB2) genes in an Australian case-control Caucasian population for association with migraine. Both candidate genes are highly expressed in the central nervous system (CNS) and fit criteria for migraine neuropathology. SNPs in the ADARB2 gene were previously found to be positively associated with migraine in a pedigree-based GWAS using the genetic isolate of Norfolk Island, Australia. The ADARB1 gene was also chosen for investigation due to its important function in editing neurotransmitter receptor transcripts.

Methods:

Four SNPs in ADARB1 and nine in ADARB2 were selected by inspecting blocks of LD in Haploview for genotyping using either TaqMan or Sequenom assays. These SNPs were genotyped in two-hundred and ninety one patients who satisfied the International Classification of Headache Disorders, ICHD-II 2004 diagnostic criteria for migraine and three-hundred and fourteen controls and PLINK was used for association testing.

Results:

Chi-square (χ2) analysis found no significant association between any of the SNPs tested in the ADARB1 and ADARB2 genes in this study and the occurrence of migraine.

Conclusions:

In contrast to findings that SNPs in the ADARB2 gene were positively associated with migraine in the Norfolk Island population, we find no evidence to support the involvement of RNA editing genes in migraine susceptibility in an Australian Caucasian population.

Impact and interest:

1 citations in Scopus
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ID Code: 87084
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Migraine, Migraine with aura, Migraine without aura, RNA editing, pGWAS, Norfolk Island, ADARB1, ADARB2, headache
DOI: 10.1186/s10194-015-0511-y
ISSN: 1129-2377
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: © 2015 Gaspirini et al.; licensee Springer.
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Deposited On: 02 Sep 2015 00:20
Last Modified: 05 Sep 2015 06:55

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