Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis

Oswari, Hanifah, Widjaja, Ruth Karisma, Rohsiswatmo, Rinawati, & Cleghorn, Geoffrey J. (2013) Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis. Journal of Paediatrics & Child Health, 49(1), E6-E11.

View at publisher

Abstract

Aims The aim of the study was to evaluate the significance of total bilirubin, aspartate transaminase (AST), alanine transaminase and gamma-glutamyltransferase (GGT) for predicting outcome in sepsis-associated cholestasis.

Methods: A retrospective cohort review of the hospital records was performed in 181 neonates admitted to the Neonatal Care Unit. A comparison was performed between subjects with low and high liver values based on cut-off values from ROC analysis. We defined poor prognosis to be when a subject had prolonged cholestasis of more than 3.5 months, developed severe sepsis, septic shock or had a fatal outcome.

Results: The majority of the subjects were male (56%), preterm (56%) and had early onset sepsis (73%). The poor prognosis group had lower initial values of GGT compared with the good prognosis group (P = 0.003). Serum GGT (cut-off value of 85.5 U/L) and AST (cut-off value of 51 U/L) showed significant correlation with the outcome following multivariate analysis. The odds ratio (OR) of low GGT and high AST were OR 4.3 (95% CI:1.6 to11.8) and OR 2.9 (95% CI:1.1 to 8), respectively, for poor prognosis. In subjects with normal AST values, those with low GGT value had relative risk of 2.52 (95% CI:1.4 to 3.5) for poorer prognosis compared with those with normal or high GGT.

Conclusion: Serum GGT and AST values can be used to predict the prognosis of patients with sepsis-associated cholestasis

Impact and interest:

2 citations in Scopus
Search Google Scholar™
2 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 87170
Item Type: Journal Article
Refereed: Yes
Additional Information: Article first published online: 21 DEC 2012
Keywords: Ast, Bilirubin, Ggt, Sepsis associated cholestasis, Gamma Glutamyltransferase, Infants, Inflammation, Hepatitis
DOI: 10.1111/jpc.12053
ISSN: 1034-4810
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Copyright Owner: Wiley-Blackwell Publishing
Deposited On: 02 Sep 2015 02:48
Last Modified: 03 Sep 2015 00:32

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page