Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis

Oswari, Hanifah, Widjaja, Ruth Karisma, Rohsiswatmo, Rinawati, & Cleghorn, Geoffrey J. (2013) Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis. Journal of Paediatrics & Child Health, 49(1), E6-E11.

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Aims The aim of the study was to evaluate the significance of total bilirubin, aspartate transaminase (AST), alanine transaminase and gamma-glutamyltransferase (GGT) for predicting outcome in sepsis-associated cholestasis.

Methods: A retrospective cohort review of the hospital records was performed in 181 neonates admitted to the Neonatal Care Unit. A comparison was performed between subjects with low and high liver values based on cut-off values from ROC analysis. We defined poor prognosis to be when a subject had prolonged cholestasis of more than 3.5 months, developed severe sepsis, septic shock or had a fatal outcome.

Results: The majority of the subjects were male (56%), preterm (56%) and had early onset sepsis (73%). The poor prognosis group had lower initial values of GGT compared with the good prognosis group (P = 0.003). Serum GGT (cut-off value of 85.5 U/L) and AST (cut-off value of 51 U/L) showed significant correlation with the outcome following multivariate analysis. The odds ratio (OR) of low GGT and high AST were OR 4.3 (95% CI:1.6 to11.8) and OR 2.9 (95% CI:1.1 to 8), respectively, for poor prognosis. In subjects with normal AST values, those with low GGT value had relative risk of 2.52 (95% CI:1.4 to 3.5) for poorer prognosis compared with those with normal or high GGT.

Conclusion: Serum GGT and AST values can be used to predict the prognosis of patients with sepsis-associated cholestasis

Impact and interest:

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ID Code: 87170
Item Type: Journal Article
Refereed: Yes
Additional Information: Article first published online: 21 DEC 2012
Keywords: Ast, Bilirubin, Ggt, Sepsis associated cholestasis, Gamma Glutamyltransferase, Infants, Inflammation, Hepatitis
DOI: 10.1111/jpc.12053
ISSN: 1034-4810
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Copyright Owner: Wiley-Blackwell Publishing
Deposited On: 02 Sep 2015 02:48
Last Modified: 03 Sep 2015 00:32

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