Mechanisms of signal transduction utilized by growth hormone

Shafiei, Farhad, Herington, Adrian C., & Lobie, Peter E. (2006) Mechanisms of signal transduction utilized by growth hormone. In Nyberg, Fred (Ed.) The somatotrophic axis in brain function. Elsevier, Burlington, MA., pp. 39-49.


In recent years, significant progress has been made in elucidating the signaling pathways activated by the growth hormone (GH) receptor. This chapter provides a discourse on the structural and functional characteristics of the GH receptor, as well as the signaling pathways demonstrated to be utilized by GH. Activation of these pathways results in various biochemical and biological outcomes, which are rapidly being elucidated and ultimately provide a basis for understanding GH action. Accordingly, c-Src, in addition to JAK2, has emerged as a key component of GH signaling, with the ability to mediate the activation of distinct signaling pathways independently of JAK2. Together with the occurrence of both positive and negative regulators, this adds further complexity to the signal transduction mechanisms utilized by GH.

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ID Code: 8724
Item Type: Book Chapter
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
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Keywords: Growth hormone, signalling pathways
ISBN: 0-12-088484-4, 978-0-12-088484-1
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Endocrinology (110306)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Elsevier
Deposited On: 23 Jul 2007 00:00
Last Modified: 29 Feb 2012 13:18

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