A candidate gene association study for growth performance in an improved Giant Freshwater Prawn (Macrobrachium rosenbergii) culture line

Jung, Hyungtaek, Lyons, Russell E., Li, Yutao, Thanh, Nguyen Minh, Dinh, Hung, Hurwood, David A., Salin, Krishna R., & Mather, Peter B. (2014) A candidate gene association study for growth performance in an improved Giant Freshwater Prawn (Macrobrachium rosenbergii) culture line. Marine Biotechnology, 16(2), pp. 161-180.

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A candidate gene approach using type I single nucleotide polymorphism (SNP) markers can provide an effective method for detecting genes and gene regions that underlie phenotypic variation in adaptively significant traits. In the absence of available genomic data resources, transcriptomes were recently generated in Macrobrachium rosenbergii to identify candidate genes and markers potentially associated with growth. The characterisation of 47 candidate loci by ABI re-sequencing of four cultured and eight wild samples revealed 342 putative SNPs. Among these, 28 SNPs were selected in 23 growth-related candidate genes to genotype in 200 animals selected for improved growth performance in an experimental GFP culture line in Vietnam. The associations between SNP markers and individual growth performance were then examined. For additive and dominant effects, a total of three exonic SNPs in glycogen phosphorylase (additive), heat shock protein 90 (additive and dominant) and peroxidasin (additive), and a total of six intronic SNPs in ankyrin repeats-like protein (additive and dominant), rolling pebbles (dominant), transforming growth factor-β induced precursor (dominant), and UTP-glucose-1-phosphate uridylyltransferase 2 (dominant) genes showed significant associations with the estimated breeding values in the experimental animals (P =0.001−0.031). Individually, they explained 2.6−4.8 % of the genetic variance (R2=0.026−0.048). This is the first large set of SNP markers reported for M. rosenbergii and will be useful for confirmation of associations in other samples or culture lines as well as having applications in marker-assisted selection in future breeding programs.

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ID Code: 87255
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: macrobrachium rosenbergii, ABI re-sequencing, growth-related candidate genes, SNPs Associations, Estimated breeding values
DOI: 10.1007/s10126-013-9555-7
ISSN: 1436-2236
Divisions: Past > Schools > Biogeoscience
Current > Research Centres > Centre for Tropical Crops and Biocommodities
Current > Schools > School of Earth, Environmental & Biological Sciences
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Springer Science + Business Media New York
Copyright Statement: The final publication is available at Springer via http://10.1007/s10126-013-9555-7
Deposited On: 09 Sep 2015 23:45
Last Modified: 14 Sep 2015 04:27

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