Investigation of the binding interactions between insulin and its receptor

Sit, Kei Chun (2015) Investigation of the binding interactions between insulin and its receptor. PhD thesis, Queensland University of Technology.


This project investigated the interactions between insulin and its receptor. A combination of computational and experimental investigations resulted in the identification of four residues in non-canonical sites that, when mutated, had detrimental effects on insulin binding. An increased understanding of the binding mechanism will aid future research into diseases involving the insulin receptor and its relatives and could potentially lead to new therapeutic avenues to combat these health related issues.

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39 since deposited on 14 Oct 2015
26 in the past twelve months

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ID Code: 87276
Item Type: QUT Thesis (PhD)
Supervisor: Croll, Tristan, Van Lonkhuyzen, Derek, & Walsh, Terry
Keywords: insulin receptor, molecular dynamics simulations, ligand binding, principal components analysis, surface plasmon resonance, protein expression, conformational change, BIAcore, protein purification, mutagenesis
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 14 Oct 2015 05:50
Last Modified: 23 Jun 2017 14:47

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