Genomewide screens in ankylosing spondylitis
Brown, Matthew A. (2009) Genomewide screens in ankylosing spondylitis. In Lopez-Larrea, Carlos & Diaz-Pena, Roberto (Eds.) Molecular Mechanisms of Spondyloarthropathies. Springer, pp. 148-158.
Efforts to identify genes other than HLA-B27 in AS have been driven by the strength of the evidence from genetic epidemiology studies indicating that HLA-B27, although a major gene in AS, is clearly not the only significant gene operating. This is the case for both genetic determinants of disease-susceptibility and phenotypic characteristics such as disease severity and associated disease features. In this chapter the genetic epidemiology of AS and the gene-mapping studies performed to date will be reviewed and the future direction of research in this field discussed.
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|Item Type:||Book Chapter|
|Additional Information:||No file attached.|
|Keywords:||caspase recruitment domain protein 15, cytochrome P450 2D6, HLA antigen, HLA B antigen, HLA B27 antigen, HLA B60 antigen, hla cw6 antigen, HLA DR antigen, HLA E antigen, interleukin 1, interleukin 1alpha, interleukin 23 receptor, non receptor protein tyrosine phosphatase 22, protein ARTS1, recombinant interleukin 1 receptor blocking agent, regulator protein, toll like receptor 4, unclassified drug, ankylosing spondylitis, article, ARTS1 gene, caspase recruitment domain protein 15 gene, cytochrome P450 2D6 gene, gene identification, gene linkage disequilibrium, gene locus, gene mapping, gene mutation, gene segregation, genetic association, genetic epidemiology, genetic screening, genetic susceptibility, genetic variability, human, interleukin 1 gene, interleukin 23 receptor gene, major histocompatibility complex, marker gene, microarray analysis, molecular pathology, nonhuman, polymerase chain reaction, priority journal, restriction fragment length polymorphism, segregation analysis, single nucleotide polymorphism, toll like receptor 4 gene, genetic linkage, genetic predisposition, genetics, immunology, review, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-B27 Antigen, Linkage (Genetics), Spondylitis, Ankylosing|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||24 Sep 2015 02:39|
|Last Modified:||31 Oct 2015 16:45|
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