The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis

Timms, A. E., Crane, A. M., Sims, A. M., Cordell, H. J., Bradbury, L. A., Abbott, A., Coyne, M. R. E., Beynon, O., Herzberg, I., Duff, G. W., Calin, A., Cardon, L. R., Wordsworth, B. P., & Brown, Matthew A. (2004) The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. American Journal of Human Genetics, 75(4), pp. 587-595.

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Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS.

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ID Code: 87700
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: HLA B27 antigen, adult, ankylosing spondylitis, arthropathy, article, chromosome 2q, controlled study, correlation analysis, female, gene, gene cluster, gene locus, genetic analysis, genetic linkage, genetic marker, genetic susceptibility, haplotype, heritability, human, inflammation, interleukin 1 gene, major clinical study, male, pathogenesis, priority journal, recurrent disease, single nucleotide polymorphism, Chromosomes, Human, Pair 2, DNA Mutational Analysis, DNA Primers, Electrophoresis, Agar Gel, Gene Frequency, Genetic Predisposition to Disease, Genotype, Great Britain, Haplotypes, HLA-B27 Antigen, Humans, Inheritance Patterns, Interleukin-1, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing
DOI: 10.1086/424695
ISSN: 0002-9297
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 24 Sep 2015 01:34
Last Modified: 24 Sep 2015 01:34

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