Matters Arising: Role of HLA genes in familial spondyloarthropathy

Brown, M A, Crane, A. M., Wordsworth, B. P., Said-Nahal, R., Miceli-Richard, C., & Breban, M. (2002) Matters Arising: Role of HLA genes in familial spondyloarthropathy. Annals of the Rheumatic Diseases, 61(8), pp. 764-765.

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Said-Nahal and colleagues report an intriguing finding of an association with HLA-DR4 independent of B27 in families with ankylosing spondylitis (AS),1 a finding highlighted by an accompanying editorial.2 The approach of studying B27 positive and B27 negative haplotypes may prove powerful in identifying further cis or trans encoded genes involved in AS. However, the reported association of DR4 with AS is quite a surprising finding given that no difference was noted in B27-DR4 haplotype frequencies in patients and ethnically matched healthy controls. Many previous studies have not reported any such association,3–9 including a similar preliminary study by the same authors.10 Although these studies were mainly case-control studies, population stratification is highly unlikely to cause a false negative finding if the effect size of the reported association with DR4 is as high as Said-Nahal and colleagues describe...

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1 citations in Web of Science®
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ID Code: 87727
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: HLA B27 antigen, HLA DR4 antigen, familial disease, genetic disorder, HLA system, human, priority journal, short survey, spondyloarthropathy, epidemiology, genetics, note, pedigree, Bias (Epidemiology), HLA-B27 Antigen, Spondylarthropathies, Humans
DOI: 10.1136/ard.61.8.764
ISSN: 0003-4967
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 25 Sep 2015 01:24
Last Modified: 25 Sep 2015 01:24

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