HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom

Brown, M A, Pile, K. D., Kennedy, L. G., Calin, A., Darke, C., Bell, J., Wordsworth, B. P., & Cornélis, F. (1996) HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. Annals of the Rheumatic Diseases, 55(4), pp. 268-270.

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Objective -

To investigate the HLA class I associations of ankylosing spondylitis (AS) in the white population, with particular reference to HLA-B27 subtypes.

Methods -

HLA-B27 and -B60 typing was performed in 284 white patients with AS. Allele frequencies of HLA-B27 and HLA-B60 from 5926 white bone marrow donors were used for comparison. HLA-B27 subtyping was performed by single strand conformation polymorphism (SSCP) in all HLA-B27 positive AS patients, and 154 HLA-B27 positive ethnically matched blood donors.

Results -

The strong association of HLA-B27 and AS was confirmed (odds ratio (OR) 171, 95% confidence interval (CI) 135 to 218; p < 10-99). The association of HLA-B60 with AS was confirmed in HLA-B27 positive cases (OR 3.6, 95% CI 2.1 to 6.3; p < 5 x 10-5), and a similar association was demonstrated in HLA-B27 negative AS (OR 3.5, 95% CI 1.1 to 11.4; p < 0.05). No significant difference was observed in the frequencies of HLA-B27 allelic subtypes in patients and controls (HLA-B2702, three of 172 patients v five of 154 controls; HLA-B2705, 169 of 172 patients v 147 of 154 controls; HkA-B*2708, none of 172 patients v two of 154 controls), and no novel HLA-B27 alleles were detected.

Conclusion -

HLA-B27 and -B60 are associated with susceptibility to AS, but differences in BLA-B27 subtype do not affect susceptibility to AS in this white population.

Impact and interest:

178 citations in Scopus
151 citations in Web of Science®
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ID Code: 87730
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: HLA antigen class 1, HLA B27 antigen, ankylosing spondylitis, article, blood donor, bone marrow, genetic polymorphism, genotype, human, major clinical study, phenotype, polymerase chain reaction, priority journal, united kingdom, Alleles, Base Sequence, Case-Control Studies, Disease Susceptibility, European Continental Ancestry Group, Histocompatibility Testing, HLA-B Antigens, HLA-B27 Antigen, Humans, Molecular Sequence Data, Polymorphism, Single-Stranded Conformational, Spondylitis, Ankylosing
DOI: 10.1136/ard.55.4.268
ISSN: 0003-4967
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 25 Sep 2015 02:04
Last Modified: 25 Sep 2015 02:04

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