Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis

Harvey, D., Pointon, J. J., Sleator, C., Meenagh, A., Farrar, C., Sun, J. Y., Senitzer, D., Middleton, D., Brown, M A, & Wordsworth, B. P. (2009) Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis. Annals of the Rheumatic Diseases, 68(4), pp. 595-598.

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To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS).

Methods: 14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the χp2p test.


KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls.


Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.

Impact and interest:

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19 citations in Web of Science®

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ID Code: 87739
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: killer cell immunoglobulin like receptor, killer cell immunoglobulin like receptor 3DL1, killer cell immunoglobulin like receptor 3DL2, killer cell immunoglobulin like receptor 3DS1, KIR3DL1 protein, human, KIR3DL2 protein, human, ankylosing spondylitis, article, clinical assessment, control group, controlled study, gene frequency, genetic analysis, genetic association, genotype, human, major clinical study, multiplex polymerase chain reaction, nucleotide sequence, oligonucleotide probe, priority journal, United Kingdom, allele, case control study, chi square distribution, genetics, haplotype, methodology, polymerase chain reaction, risk, Alleles, Case-Control Studies, Chi-Square Distribution, Haplotypes, Humans, Odds Ratio, Receptors, KIR, Receptors, KIR3DL1, Receptors, KIR3DL2, Receptors, KIR3DS1, Spondylitis, Ankylosing
DOI: 10.1136/ard.2008.095927
ISSN: 0003-4967
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 25 Sep 2015 01:15
Last Modified: 22 Aug 2016 05:36

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