The F158V polymorphism in FcγRIIIA shows disparate associations with rheumatoid arthritis in two genetically distinct populations

Milicic, A., Misra, R., Agrawal, S., Aggarwal, A., Brown, M A, & Wordsworth, B. P. (2002) The F158V polymorphism in FcγRIIIA shows disparate associations with rheumatoid arthritis in two genetically distinct populations. Annals of the Rheumatic Diseases, 61(11), pp. 1021-1023.

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Abstract

Objectives:

To investigate the association of the FcγRIIIA gene with rheumatoid orthritis (RA) in two genetically distinct groups: a white group from the United Kingdom and a northern Indian group.

Methods:

The distributions of the two alleles of the FcγRIIIA F158V polymorphism were determined in 398 white patients from the United Kingdom and 63 Indian patients with RA and compared with those from 289 United Kingdom and 93 Indian healthy controls, respectively.

Results:

Among the Indian patients, the frequency of the rare 158V allele and the proportion of 158VV homozygotes were reduced (relative risk (RR)=0.3, 95% confidence interval (95% CI) 0.1 to 1.1, p<0.06), reaching statistical significance for carrying the 158VV phenotype relative to 158FV or FF (RR=0.2, 95% CI 0.05-0.9, p<0.02). Conversely, no significant deviation in allelic frequencies was noted between the patients and controls from the United Kingdom.

Conclusions:

The 158VV phenotype showed a weak protective effect against developing RA in the Indian group. However, this sample was small (resulting in a low power for statistical analysis) and no independent confirmation was found in the larger white United Kingdom group. Thus the FcγRIIIA locus is unlikely to be of major importance in causing RA.

Impact and interest:

21 citations in Scopus
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22 citations in Web of Science®

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ID Code: 87743
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: Fc receptor, allele, article, Caucasian, controlled study, disease association, DNA polymorphism, gene frequency, gene locus, genetic association, genetic epidemiology, homozygote, human, Indian, major clinical study, phenotype, priority journal, race difference, rheumatoid arthritis, statistical significance, United Kingdom, ethnology, genetic polymorphism, genetic predisposition, genetics, genotype, India, Alleles, Arthritis, Rheumatoid, Genetic Predisposition to Disease, Great Britain, Humans, Polymorphism, Genetic, Receptors, IgG
DOI: 10.1136/ard.61.11.1021
ISSN: 0003-4967
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 24 Sep 2015 04:48
Last Modified: 24 Sep 2015 04:48

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