The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest‐lived mammal

Seim, Inge, Ma, Siming, Zhou, Xuming, Gerashchenko, Maxim V., Lee, Sang-Goo, Suydam, Robert, George, John C., Bickham, John W., & Gladyshev, Vadim N. (2014) The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest‐lived mammal. Aging, 6(10), pp. 879-899.

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Abstract

Mammals vary dramatically in lifespan, by at least two-orders of magnitude, but the molecular basis for this difference remains largely unknown. The bowhead whale Balaena mysticetus is the longest-lived mammal known, with an estimated maximal lifespan in excess of two hundred years. It is also one of the two largest animals and the most cold-adapted baleen whale species. Here, we report the first genome-wide gene expression analyses of the bowhead whale, based on the de novo assembly of its transcriptome. Bowhead whale or cetacean-specific changes in gene expression were identified in the liver, kidney and heart, and complemented with analyses of positively selected genes. Changes associated with altered insulin signaling and other gene expression patterns could help explain the remarkable longevity of bowhead whales as well as their adaptation to a lipid-rich diet. The data also reveal parallels in candidate longevity adaptations of the bowhead whale, naked mole rat and Brandt's bat. The bowhead whale transcriptome is a valuable resource for the study of this remarkable animal, including the evolution of longevity and its important correlates such as resistance to cancer and other diseases.

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ID Code: 87852
Item Type: Journal Article
Refereed: Yes
Keywords: bowhead whale, transcriptome, insulin/IGF1-axis, aging, evolution
ISSN: 1945-4589
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Seim et al.
Copyright Statement: This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Deposited On: 29 Sep 2015 22:53
Last Modified: 09 Oct 2015 00:20

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