Is there a higher genetic load of susceptibility loci in familial ankylosing spondylitis?

Joshi, R., Reveille, J. D., Brown, Matthew A., Weisman, M. H., Ward, M. M., Gensler, L. S., Wordsworth, B. P., Evans, D. M., & Assassi, S. (2012) Is there a higher genetic load of susceptibility loci in familial ankylosing spondylitis? Arthritis Care & Research, 64(5), pp. 780-784.

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Abstract

Objective

Several genetic risk variants for ankylosing spondylitis (AS) have been identified in genome-wide association studies. Our objective was to examine whether familial AS cases have a higher genetic load of these susceptibility variants.

Methods

Overall, 502 AS patients were examined, consisting of 312 patients who had first-degree relatives (FDRs) with AS (familial) and 190 patients who had no FDRs with AS or spondylarthritis (sporadic). All patients and affected FDRs fulfilled the modified New York criteria for AS. The patients were recruited from 2 US cohorts (the North American Spondylitis Consortium and the Prospective Study of Outcomes in Ankylosing Spondylitis) and from the UK-Oxford cohort. The frequencies of AS susceptibility loci in IL-23R, IL1R2, ANTXR2, ERAP-1, 2 intergenic regions on chromosomes 2p15 and 21q22, and HLA-B27 status as determined by the tag single-nucleotide polymorphism (SNP) rs4349859 were compared between familial and sporadic cases of AS. Association between SNPs and multiplex status was assessed by logistic regression controlling for sibship size.

Results

HLA-B27 was significantly more prevalent in familial than sporadic cases of AS (odds ratio 4.44 [95% confidence interval 2.06, 9.55], P = 0.0001). Furthermore, the AS risk allele at chromosome 21q22 intergenic region showed a trend toward higher frequency in the multiplex cases (P = 0.08). The frequency of the other AS risk variants did not differ significantly between familial and sporadic cases, either individually or combined.

Conclusion

HLA-B27 is more prevalent in familial than sporadic cases of AS, demonstrating higher familial aggregation of AS in patients with HLA-B27 positivity. The frequency of the recently described non-major histocompatibility complex susceptibility loci is not markedly different between the sporadic and familial cases of AS.

Impact and interest:

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ID Code: 87859
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: adult, ankylosing spondylitis, article, clinical trial, cohort analysis, comparative study, cross-sectional study, female, gene locus, genetic association, genetic load, genetic predisposition, genetics, human, longitudinal study, male, methodology, middle aged, multicenter study, prospective study, single nucleotide polymorphism, Cohort Studies, Cross-Sectional Studies, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Longitudinal Studies, Polymorphism, Single Nucleotide, Prospective Studies, Spondylitis, Ankylosing
DOI: 10.1002/acr.21601
ISSN: 2151-4658
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 29 Sep 2015 02:32
Last Modified: 16 Feb 2016 00:12

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