Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitis

Brown, Matthew A (2009) Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitis. Arthritis Research and Therapy, 11(5).

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Abstract

The advent of high-throughput SNP genotyping methods has advanced research into the genetics of common complex genetic diseases such as ankylosing spondylitis (AS) rapidly in recent times. The identification of associations with the genes IL23R and ERAP1 have been robustly replicated, and advances have been made in studies of the major histocompatibility complex genetics of AS, and of KIR gene variants and the disease. The findings are already being translated into increased understanding of the immunological pathways involved in AS, and raising novel potential therapies. The current studies in AS remain underpowered, and no full genomewide association study has yet been reported in AS; such studies are likely to add to the significant advances that have already been made.

Impact and interest:

15 citations in Scopus
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12 citations in Web of Science®

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ID Code: 87863
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: HLA B antigen, HLA B27 antigen, interleukin 23 receptor, ankylosing spondylitis, gene, gene identification, gene replication, genetic association, genetic susceptibility, genetic variability, genotype, high throughput screening, human, major histocompatibility complex, microsatellite marker, review, single nucleotide polymorphism, genetic predisposition, genetics, immunology, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing
DOI: 10.1186/ar2692
ISSN: 1478-6354
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 29 Sep 2015 04:48
Last Modified: 22 Aug 2016 04:36

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