Promise and pitfalls of the Immunochip
Cortes, A. & Brown, Matthew A (2010) Promise and pitfalls of the Immunochip. Arthritis Research and Therapy, 13(1).
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.
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|Item Type:||Journal Article|
|Additional Information:||No file attached.|
|Keywords:||ankylosing spondylitis, autoimmune thyroiditis, Caucasian, celiac disease, copy number variation, Crohn disease, epigenetics, gene identification, gene interaction, gene locus, gene mapping, gene replication, genetic association, genetic disorder, genetic variability, genotype, genotype environment interaction, health care cost, heritability, human, immunochip, immunogenetics, insulin dependent diabetes mellitus, multiple sclerosis, note, psoriasis, race difference, rheumatoid arthritis, sample size, single nucleotide polymorphism, systemic lupus erythematosus, ulcerative colitis|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||29 Sep 2015 04:38|
|Last Modified:||29 Sep 2015 04:38|
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