Microbes, the gut and ankylosing spondylitis

Costello, Mary-Ellen, Elewaut, Dirk, Kenna, Tony J., & Brown, Matthew A. (2013) Microbes, the gut and ankylosing spondylitis. Arthritis Research and Therapy, 15, Article Number:-214.

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It is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intestine contains approximately 100 trillion bacteria. Interrogation of microbial communities by using classic microbiology techniques offers a very restricted view of these communities, allowing us to see only what we can grow in isolation. However, recent advances in sequencing technologies have greatly facilitated systematic and comprehensive studies of the role of the microbiome in human health and disease. Comprehensive understanding of our microbiome will enhance understanding of disease pathogenesis, which in turn may lead to rationally targeted therapy for a number of conditions, including autoimmunity.

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21 citations in Scopus
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20 citations in Web of Science®

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ID Code: 87866
Item Type: Journal Article
Refereed: Yes
Keywords: interleukin 23, adaptive immunity, ankylosing spondylitis, arthritis, Campylobacter, enteropathy, gamm delta T lymphocyte, human, innate immunity, intestine, intestine epithelium cell, lymphoid cell, lymphoid tissue, metagenomics, microbiome, microorganism, natural killer T cell, nonhuman, review, Salmonella, Shigella, T lymphocyte, Yersinia
DOI: 10.1186/ar4228
ISSN: 1478-6354
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: 2013 BioMed Central Ltd
Deposited On: 29 Sep 2015 04:20
Last Modified: 22 Mar 2016 06:52

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