Genetic studies in osteoporosis: The end of the beginning

Duncan, Emma L. & Brown, Matthew A. (2008) Genetic studies in osteoporosis: The end of the beginning. Arthritis Research and Therapy, 10(5), Artical Number:-214.

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Osteoporosis and disorders of bone fragility are highly heritable, but despite much effort the identities of few of the genes involved has been established. Recent developments in genetics such as genome-wide association studies are revolutionizing research in this field, and it is likely that further contributions will be made through application of next-generation sequencing technologies, analysis of copy number variation polymorphisms, and high-throughput mouse mutagenesis programs. This article outlines what we know about osteoporosis genetics to date and the probable future directions of research in this field.

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ID Code: 87867
Item Type: Journal Article
Refereed: Yes
Keywords: alkaline phosphatase, calcium sensing receptor, carbonate dehydratase II, cathepsin K, chloride channel, collagen type 1, low density lipoprotein receptor related protein 5, membrane protein, osteoprotegerin, oxygenase, procollagen lysine 2 oxoglutarate 5 dioxygenase, receptor activator of nuclear factor kappa B, sclerostin, bone fragility, gene number, gene technology, genetic association, genetic identification, genetic polymorphism, genetic susceptibility, genetic variability, high throughput screening, human, mutagenesis, nonhuman, osteoporosis, prevalence, review, sequence analysis, animal, clinical trial, genetic predisposition, genetics, Animals, Clinical Trials as Topic, Genetic Predisposition to Disease, Humans
DOI: 10.1186/ar2479
ISSN: 1478-6354
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 The Author(s)
Deposited On: 29 Sep 2015 04:23
Last Modified: 03 May 2016 01:26

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