Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: The population-based Nord-Trøndelag health study (HUNT)

Pahau, Helen, Brown, Matthew A., Paul, Sanjoy, Thomas, Ranjeny, & Videm, Vibeke (2014) Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: The population-based Nord-Trøndelag health study (HUNT). Arthritis Research and Therapy, 16, Article Number:-R85.

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Patients with rheumatoid arthritis (RA) have increased risk of cardiovascular (CV) events. We sought to test the hypothesis that due to increased inflammation, CV disease and risk factors are associated with increased risk of future RA development.


The population-based Nord-Trøndelag health surveys (HUNT) were conducted among the entire adult population of Nord-Trøndelag, Norway. All inhabitants 20 years or older were invited, and information was collected through comprehensive questionnaires, a clinical examination, and blood samples. In a cohort design, data from HUNT2 (1995-1997, baseline) and HUNT3 (2006-2008, follow-up) were obtained to study participants with RA (n = 786) or osteoarthritis (n = 3,586) at HUNT3 alone, in comparison with individuals without RA or osteoarthritis at both times (n = 33,567).


Female gender, age, smoking, body mass index, and history of previous CV disease were associated with self-reported incident RA (previous CV disease: odds ratio 1.52 (95% confidence interval 1.11-2.07). The findings regarding previous CV disease were confirmed in sensitivity analyses excluding participants with psoriasis (odds ratio (OR) 1.70 (1.23-2.36)) or restricting the analysis to cases with a hospital diagnosis of RA (OR 1.90 (1.10-3.27)) or carriers of the shared epitope (OR 1.76 (1.13-2.74)). History of previous CV disease was not associated with increased risk of osteoarthritis (OR 1.04 (0.86-1.27)).


A history of previous CV disease was associated with increased risk of incident RA but not osteoarthritis.

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ID Code: 87869
Item Type: Journal Article
Refereed: Yes
Keywords: analgesic agent, cholesterol, triacylglycerol, adult, age, article, body mass, cardiovascular disease, cardiovascular risk, cholesterol blood level, cohort analysis, comparative study, controlled study, diabetes mellitus, diastolic blood pressure, female, follow up, Framingham risk score, gender, health survey, human, hypertension, logistic regression analysis, major clinical study, male, Norway, osteoarthritis, rheumatoid arthritis, self report, smoking, systolic blood pressure, triacylglycerol blood level, aged, Arthritis, Rheumatoid, complication, incidence, middle aged, risk factor, Cardiovascular Diseases, Humans, Risk Factors
DOI: 10.1186/ar4527
ISSN: 1478-6354
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 29 Sep 2015 04:08
Last Modified: 28 Mar 2016 23:45

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