The window of opportunity: A relevant concept for axial spondyloarthritis

Robinson, P. C. & Brown, Matthew A (2014) The window of opportunity: A relevant concept for axial spondyloarthritis. Arthritis Research and Therapy, 16(3).

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Abstract

The window of opportunity is a concept critical to rheumatoid arthritis treatment. Early treatment changes the outcome of rheumatoid arthritis treatment, in that response rates are higher with earlier disease-modifying anti-rheumatic drug treatment and damage is substantially reduced. Axial spondyloarthritis is an inflammatory axial disease encompassing both nonradiographic axial spondyloarthritis and established ankylosing spondylitis. In axial spondyloarthritis, studies of magnetic resonance imaging as well as tumor necrosis factor inhibitor treatment and withdrawal studies all suggest that early effective suppression of inflammation has the potential to reduce radiographic damage. This potential would suggest that the concept of a window of opportunity is relevant not only to rheumatoid arthritis but also to axial spondyloarthritis. The challenge now remains to identify high-risk patients early and to commence treatment without delay. Developments in risk stratification include new classification criteria, identification of clinical risk factors, biomarkers, genetic associations, potential antibody associations and an ankylosing spondylitis-specific microbiome signature. Further research needs to focus on the evidence for early intervention and the early identification of high-risk individuals.

Impact and interest:

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6 citations in Web of Science®

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ID Code: 87871
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: tumor necrosis factor inhibitor, antirheumatic agent, tumor necrosis factor alpha, ankylosing spondylitis, article, axial spondyloarthritis, genetic association, high risk patient, human, immunosuppressive treatment, inflammatory disease, nuclear magnetic resonance imaging, risk factor, spondylarthritis, antagonists and inhibitors, Arthritis, Rheumatoid, outcome assessment, procedures, Spondylitis, Ankylosing, time, Antirheumatic Agents, Humans, Magnetic Resonance Imaging, Outcome Assessment (Health Care), Time Factors, Tumor Necrosis Factor-alpha
DOI: 10.1186/ar4561
ISSN: 1478-6354
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 29 Sep 2015 04:02
Last Modified: 16 Feb 2016 01:54

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