The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis

Costello, Mary-Ellen, Robinson, Philip C., Benham, Helen, & Brown, Matthew A. (2015) The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis. Best Practice and Research: Clinical Rheumatology, 29(2), pp. 202-212.

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Abstract

Humans and microbes have developed a symbiotic relationship over time, and alterations in this symbiotic relationship have been linked to several immune mediated diseases such as inflammatory bowel disease, type 1 diabetes and spondyloarthropathies. Improvements in sequencing technologies, coupled with a renaissance in 16S rRNA gene based community profiling, have enabled the characterization of microbiomes throughout the body including the gut. Improved characterization and understanding of the human gut microbiome means the gut flora is progressively being explored as a target for novel therapies including probiotics and faecal microbiota transplants. These innovative therapies are increasingly used for patients with debilitating conditions where conventional treatments have failed. This review discusses the current understanding of the interplay between host genetics and the gut microbiome in the pathogenesis of spondyloarthropathies, and how this may relate to potential therapies for these conditions.

Impact and interest:

3 citations in Scopus
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2 citations in Web of Science®

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ID Code: 87875
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: Dysbiosis, Faecal microbiota transplant, Intestinal microbiome, Spondyloarthritis, ankylosing spondylitis, arthritis, disease association, experimental therapy, feces microflora, genetics, homeostasis, human, insulin dependent diabetes mellitus, intestine flora, metagenome, microbial community, microbiome, nonhuman, priority journal, Review, spondylarthritis, spondyloarthropathy
DOI: 10.1016/j.berh.2015.08.001
ISSN: 1521-6942
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 01 Oct 2015 02:21
Last Modified: 18 Oct 2015 22:41

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