Mapping genes for osteoporosis-Old dogs and new tricks
In stark contrast to its horticultural origins, modern genetics is an extremely technology-driven field. Almost all the major advances in the field over the past 20 years have followed technological developments that have permitted change in study designs. The development of PCR in the 1980s led to RFLP mapping of monogenic diseases. The development of fluorescent-tagged genotyping methods led to linkage mapping approaches for common diseases that dominated the 1990s. The development of microarray SNP genotyping has led to the genome-wide association study era of the new millennium. And now the development of next-generation sequencing technologies is about to open up a new era of gene-mapping, enabling many potential new study designs. This review aims to present the strengths and weaknesses of the current approaches, and present some new ideas about gene-mapping approaches that are likely to advance our knowledge of the genes involved in heritable bone traits such as bone mineral density (BMD) and fracture.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||No file attached.|
|Keywords:||Association, Bone, Genetics, Sequencing, SNP, gene product, interleukin 23 receptor, lactase, low density lipoprotein receptor related protein 5, osteoclast differentiation factor, protein ESR1, unclassified drug, bone density, copy number variant, ethnicity, gene linkage disequilibrium, gene mapping, gene technology, genetic association, genetic variability, human, nonhuman, osteoporosis, polymerase chain reaction, review, sample size, sequence analysis, single nucleotide polymorphism, Animals, Chromosome Mapping, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Statement:||Copyright 2010 Elsevier|
|Deposited On:||01 Oct 2015 02:23|
|Last Modified:||22 Aug 2016 01:39|
Repository Staff Only: item control page