Mapping genes for osteoporosis-Old dogs and new tricks

Duncan, Emma L. & Brown, Matthew A. (2010) Mapping genes for osteoporosis-Old dogs and new tricks. Bone, 46(5), pp. 1219-1225.

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In stark contrast to its horticultural origins, modern genetics is an extremely technology-driven field. Almost all the major advances in the field over the past 20 years have followed technological developments that have permitted change in study designs. The development of PCR in the 1980s led to RFLP mapping of monogenic diseases. The development of fluorescent-tagged genotyping methods led to linkage mapping approaches for common diseases that dominated the 1990s. The development of microarray SNP genotyping has led to the genome-wide association study era of the new millennium. And now the development of next-generation sequencing technologies is about to open up a new era of gene-mapping, enabling many potential new study designs. This review aims to present the strengths and weaknesses of the current approaches, and present some new ideas about gene-mapping approaches that are likely to advance our knowledge of the genes involved in heritable bone traits such as bone mineral density (BMD) and fracture.

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ID Code: 87876
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: Association, Bone, Genetics, Sequencing, SNP, gene product, interleukin 23 receptor, lactase, low density lipoprotein receptor related protein 5, osteoclast differentiation factor, protein ESR1, unclassified drug, bone density, copy number variant, ethnicity, gene linkage disequilibrium, gene mapping, gene technology, genetic association, genetic variability, human, nonhuman, osteoporosis, polymerase chain reaction, review, sample size, sequence analysis, single nucleotide polymorphism, Animals, Chromosome Mapping, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide
DOI: 10.1016/j.bone.2009.12.035
ISSN: 8756-3282
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Statement: Copyright 2010 Elsevier
Deposited On: 01 Oct 2015 02:23
Last Modified: 22 Aug 2016 01:39

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