The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis

Brown, M.A., Rudwaleit, M., Pile, K. D., Kennedy, L. G., Shatford, J., Amos, C. I., Siminovitch, K., Rubin, L., Calin, A., & Wordsworth, B. P. (1998) The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis. British Journal of Rheumatology, 37(4), pp. 454-458.

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Abstract

The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda ≤ 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis.

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10 citations in Scopus
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8 citations in Web of Science®

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ID Code: 87880
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: Ankylosing spondylitis, Genetics, Linkage, Microsatellite, Polymorphism, Spondyloarthritis, T-cell receptor, microsatellite dna, t lymphocyte receptor, article, controlled study, dna polymorphism, family study, genetic linkage, genetic susceptibility, human, major clinical study, normal human, priority journal, sibling, Family Health, Female, Genetic Heterogeneity, Germ-Line Mutation, Humans, Linkage (Genetics), Male, Microsatellite Repeats, Nuclear Family, Polymorphism, Genetic, Receptors, Antigen, T-Cell, Spondylitis, Ankylosing
DOI: 10.1093/rheumatology/37.4.454
ISSN: 0263-7103
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 01 Oct 2015 02:36
Last Modified: 18 Oct 2015 22:58

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