Specific IgE recognition of pollen allergens from subtropic grasses in patients from the subtropics

Nony, Emmanuel, Timbrell, Victoria, Hrabina, Maud, Boutron, Mélanie, Solley, Graham, Moingeon, Philippe, & Davies, Janet M. (2015) Specific IgE recognition of pollen allergens from subtropic grasses in patients from the subtropics. Annals of Allergy, Asthma and Immunology, 114(3), pp. 214-220.

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Pollens of subtropical grasses, Bahia (Paspalum notatum), Johnson (Sorghum halepense), and Bermuda (Cynodon dactylon), are common causes of respiratory allergies in subtropical regions worldwide. Objective To evaluate IgE cross-reactivity of grass pollen (GP) found in subtropical and temperate areas.


Case and control serum samples from 83 individuals from the subtropical region of Queensland were tested for IgE reactivity with GP extracts by enzyme-linked immunosorbent assay. A randomly sampled subset of 21 serum samples from patients with subtropical GP allergy were examined by ImmunoCAP and cross-inhibition assays.


Fifty-four patients with allergic rhinitis and GP allergy had higher IgE reactivity with P notatum and C dactylon than with a mixture of 5 temperate GPs. For 90% of 21 GP allergic serum samples, P notatum, S halepense, or C dactylon specific IgE concentrations were higher than temperate GP specific IgE, and GP specific IgE had higher correlations of subtropical GP (r = 0.771-0.950) than temperate GP (r = 0.317-0.677). In most patients (71%-100%), IgE with P notatum, S halepense, or C dactylon GPs was inhibited better by subtropical GP than temperate GP. When the temperate GP mixture achieved 50% inhibition of IgE with subtropical GP, there was a 39- to 67-fold difference in concentrations giving 50% inhibition and significant differences in maximum inhibition for S halepense and P notatum GP relative to temperate GP.


Patients living in a subtropical region had species specific IgE recognition of subtropical GP. Most GP allergic patients in Queensland would benefit from allergen specific immunotherapy with a standardized content of subtropical GP allergens.

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ID Code: 87894
Item Type: Journal Article
Refereed: Yes
Keywords: immunoglobulin E, pollen antigen, allergen, plant antigen, plant extract, adult, allergic rhinitis, Anthoxanthum odoratum, antigen expression, Article, Australia, controlled study, cross reaction, Cynodon dactylon, Dactylis glomerata, female, grass, grass pollen, grassland, human, major clinical study, male, middle aged, nonhuman, Paspalum notatum, perennial ryegrass, Phleum pratense, Poa pratensis, pollen allergy, priority journal, Sorghum halepense, subtropic grassland, temperate grassland, blood, case control study, Cynodon, desensitization, immunology, Paspalum, pollen, randomization, sorghum, Allergens, Antigens, Plant, Case-Control Studies, Cross Reactions, Desensitization, Immunologic, Humans, Plant Extracts, Random Allocation, Rhinitis, Allergic, Seasonal
DOI: 10.1016/j.anai.2014.12.005
ISSN: 1081-1206
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright © 2015 Elsevier B.V
Deposited On: 01 Oct 2015 01:25
Last Modified: 01 Oct 2015 23:14

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