Grass pollen allergens globally: The contribution of subtropical grasses to burden of allergic respiratory diseases

Davies, J.M. (2014) Grass pollen allergens globally: The contribution of subtropical grasses to burden of allergic respiratory diseases. Clinical and Experimental Allergy, 44(6), pp. 790-801.

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Abstract

Grass pollens of the temperate (Pooideae) subfamily and subtropical subfamilies of grasses are major aeroallergen sources worldwide. The subtropical Chloridoideae (e.g. Cynodon dactylon; Bermuda grass) and Panicoideae (e.g. Paspalum notatum; Bahia grass) species are abundant in parts of Africa, India, Asia, Australia and the Americas, where a large and increasing proportion of the world's population abide. These grasses are phylogenetically and ecologically distinct from temperate grasses. With the advent of global warming, it is conceivable that the geographic distribution of subtropical grasses and the contribution of their pollen to the burden of allergic rhinitis and asthma will increase. This review aims to provide a comprehensive synthesis of the current global knowledge of (i) regional variation in allergic sensitivity to subtropical grass pollens, (ii) molecular allergenic components of subtropical grass pollens and (iii) allergic responses to subtropical grass pollen allergens in relevant populations. Patients from subtropical regions of the world show higher allergic sensitivity to grass pollens of Chloridoideae and Panicoideae grasses, than to temperate grass pollens. The group 1 allergens are amongst the allergen components of subtropical grass pollens, but the group 5 allergens, by which temperate grass pollen extracts are standardized for allergen content, appear to be absent from both subfamilies of subtropical grasses. Whilst there are shared allergenic components and antigenic determinants, there are additional clinically relevant subfamily-specific differences, at T- and B-cell levels, between pollen allergens of subtropical and temperate grasses. Differential immune recognition of subtropical grass pollens is likely to impact upon the efficacy of allergen immunotherapy of patients who are primarily sensitized to subtropical grass pollens. The literature reviewed herein highlights the clinical need to standardize allergen preparations for both types of subtropical grass pollens to achieve optimal diagnosis and treatment of patients with allergic respiratory disease in subtropical regions of the world. © 2014 John Wiley & Sons Ltd.

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19 citations in Web of Science®
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ID Code: 87901
Item Type: Journal Article
Refereed: Yes
Keywords: coat protein, grass pollen extract, immunoglobulin E, pollen antigen, allergen, Africa, allergic rhinitis, antigen recognition, Asia, asthma, Australia, barley, cross reaction, Cynodon dactylon, Dactylis glomerata, Eragrostis, geographic distribution, grass pollen, greenhouse effect, human, immunotherapy, India, maize, nonhuman, occupational exposure, Paspalum dilatatum, Paspalum notatum, pearl millet, perennial ryegrass, Phleum pratense, Poa pratensis, pollen allergy, prick test, priority journal, protein expression, respiratory tract allergy, review, rye, sorghum, Sorghum halepense, sugarcane, Triticum aestivum, Western Hemisphere, health, immunology, Poaceae, pollen, Respiratory Hypersensitivity, tropic climate, Allergens, Cross Reactions, Global Health, Humans, Tropical Climate
DOI: 10.1111/cea.12317
ISSN: 0954-7894
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 30 Sep 2015 04:05
Last Modified: 01 Oct 2015 04:04

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