The enigma of IgE+ B-cell memory in human subjects

Davies, Janet M., Platts-Mills, Thomas A., & Aalberse, Rob C. (2013) The enigma of IgE+ B-cell memory in human subjects. Journal of Allergy and Clinical Immunology, 131(4), pp. 972-976.

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Abstract

Our understanding of the origin and fate of the IgE-switched B cell has been markedly improved by studies in mouse models. The immediate precursor of the IgE-switched B cell is either a relatively naive nonswitched B cell or a mature IgG-switched B cell. These 2 routes are referred to as the direct and indirect pathways, respectively. IgE responses derived from each pathway differ significantly, largely reflecting the difference in time spent in a germinal center and thus time for clonal expansion, somatic hypermutation, affinity maturation, and acquisition of a memory phenotype. The clinical and therapeutic implications for IgE responses in human subjects are still a matter of debate, largely because the immunization procedures used in the animal models are significantly different from classical atopic sensitization to allergens from pollen and mites. On the basis of the limited information available, it seems likely that these atopic IgE responses are characterized by a relatively low IgG/IgE ratio, low B-cell memory, and modest affinity maturation, which fits well with the direct switching pathway. It is still unresolved how the IgE response evolves to cover a wide epitope repertoire involving many epitopes per allergen, as well as many different allergens from a single allergen source. © 2013 American Academy of Allergy, Asthma & Immunology.

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ID Code: 87902
Item Type: Journal Article
Refereed: Yes
Keywords: allergy, B cells, germinal center, IgE, IgE+ B cells, memory B cells, plasma cells, CD23 antigen, epitope, green fluorescent protein, immunoglobulin E, immunoglobulin G, interleukin 10, interleukin 4, pollen antigen, transcriptome, yellow fluorescent protein, B lymphocyte, binding affinity, cell activation, cell compartmentalization, cell differentiation, cell expansion, cell fate, cell maturation, clonal anergy, down regulation, effector cell, gene rearrangement, human, immunization, immunoglobulin gene, immunotherapy, memory cell, Nippostrongylus brasiliensis, nonhuman, phenotype, priority journal, protein expression, review, RNA analysis, sensitization, somatic hypermutation, somatic mutation, Th2 cell, wild type, Allergens, Animals, B-Lymphocytes, Cell Proliferation, Epitopes, Humans, Hypersensitivity, Immediate, Immunoglobulin Class Switching, Immunologic Memory, Mice
DOI: 10.1016/j.jaci.2012.12.1569
ISSN: 0091-6749
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 30 Sep 2015 03:51
Last Modified: 01 Oct 2015 04:10

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