Altered immunoglobulin E diversity and regulation of allergic inflammation in asthma

Davies, J. M. (2009) Altered immunoglobulin E diversity and regulation of allergic inflammation in asthma. Clinical and Experimental Allergy, 39(4), pp. 455-457.

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Abstract

The clinical efficacy of anti-immunoglobulin E (IgE) therapy indicates a central role for IgE in perpetuation of allergic inflammatory diseases. Omalizumab is now uti- lized in treatment of a wide variety of allergic conditions including severe asthma, allergic rhinitis, atopic dermati- tis, food allergy and urticaria either alone or adjunct with other therapies such as steroid administration or allergen- specific immunotherapy [1, 2]. Current research activity is focused on the cellular and molecular mechanisms by which IgE influences the immunopathogenesis of allergic disease [3]. Increased knowledge of how IgE exerts its effects will underpin effective clinical use of anti-IgE treatment. In this issue Kerzel et al. [4] investigate the effects of altered antibo dy repertoire on the outcomes of an experimental model of allergic asthma.

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2 citations in Scopus
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2 citations in Web of Science®

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ID Code: 87913
Item Type: Journal Article
Refereed: Yes
Keywords: allergen, chemokine, cytokine, immunoglobulin E, immunoglobulin E antibody, immunoglobulin heavy chain, immunoglobulin light chain, omalizumab, steroid, allergic asthma, allergic reaction, biodiversity, complementarity determining region, editorial, genetic variability, human, immunoglobulin blood level, immunopathogenesis, immunoregulation, immunotherapy, inflammation, molecular dynamics, nonhuman, priority journal, protein function, sensitization, Animals, Asthma, B-Lymphocytes, Cytokines, Humans, Mice, Somatic Hypermutation, Immunoglobulin
DOI: 10.1111/j.1365-2222.2009.03231.x
ISSN: 0954-7894
Copyright Owner: Copyright 2009 Wiley-Blackwell Publishing Ltd.
Deposited On: 30 Sep 2015 03:12
Last Modified: 01 Oct 2015 05:02

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