Immunogenetic characteristics of immunoglobulin E in allergic disease

Davies, J. M. & O'Hehir, R. E. (2008) Immunogenetic characteristics of immunoglobulin E in allergic disease. Clinical and Experimental Allergy, 38(4), pp. 566-578.

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Patients with allergic diseases produce an excess of allergen-specific IgE, the specific effector molecule that triggers allergic reactions. The provocation for this excess IgE production is still uncertain. Current ideas include oligoclonal expansion of allergen-specific B cells emanating from germinal centres, activation by superantigen of a subset of B cells, or polyclonal B cells class switching to IgE due to an IL-4 predominance. Additionally, genetic elements contribute to a propensity for increased allergen-specific IgE production. The procedure of RT-PCR allows for amplification of infrequent IgE mRNA transcripts from B cells of atopic individuals, and so facilitates examination of expressed Ig cDNA sequences. Better knowledge of the molecular characteristics of IgE produced by patients with allergic diseases would elucidate the immunogenetic basis for elevated allergen-specific IgE levels. The 'immunogenetic footprint' of IgE transcripts may elucidate the origin and activation of IgE-producing B cells in allergic disease. Here we review studies of the immunogenetic features of IgE in allergic diseases, highlighting the major advances and the experimental limitations.

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ID Code: 87914
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: immunoglobulin E, immunoglobulin E antibody, allergic disease, allergic rhinitis, antibody specificity, asthma, atopic dermatitis, atopy, B lymphocyte activation, gene, genetic analysis, genetic transcription, genetic variability, heavy chain gene, human, immunogenetics, immunoglobulin production, molecular mechanics, nonhuman, priority journal, quantitative analysis, review, Antibodies, Antigen-Antibody Reactions, B-Lymphocytes, Humans, Hypersensitivity, Immunoglobulin G
DOI: 10.1111/j.1365-2222.2008.02941.x
ISSN: 0954-7894
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 01 Oct 2015 01:03
Last Modified: 02 Oct 2015 02:04

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