An arthritogenic alphavirus uses the α1β1 integrin collagen receptor

La Linn, M., Eble, J. A., Lübken, C., Slade, R. W., Heino, J., Davies, Janet, & Suhrbier, A. (2005) An arthritogenic alphavirus uses the α1β1 integrin collagen receptor. Virology, 336(2), pp. 229-239.

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Abstract

Ross River (RR) virus is an alphavirus endemic to Australia and New Guinea and is the aetiological agent of epidemic polyarthritis or RR virus disease. Here we provide evidence that RR virus uses the collagen-binding α1β1 integrin as a cellular receptor. Infection could be inhibited by collagen IV and antibodies specific for the β1 and α1 integrin proteins, and fibroblasts from α1-integrin-/- mice were less efficiently infected than wild-type fibroblasts. Soluble α1β1 integrin bound immobilized RR virus, and peptides representing the α1β1 integrin binding-site on collagen IV inhibited virus binding to cells. We speculate that two highly conserved regions within the cell-receptor binding domain of E2 mimic collagen and provide access to cellular collagen-binding receptors.

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23 citations in Scopus
18 citations in Web of Science®
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ID Code: 87916
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: α1β1 integrin, Collagen IV, Receptor, Ross River virus, collagen type 4, protein antibody, very late activation antigen 1, alpha1 integrin, antibody, beta 1 adrenergic receptor, virus receptor, amino acid sequence, article, binding affinity, binding site, controlled study, female, human, human cell, priority journal, protein binding, protein domain, protein expression, Ross River alpha virus, animal, chemistry, drug effect, fibroblast, genetics, HeLa cell, immunology, mouse, mouse mutant, physiology, solubility, virus replication, Alphavirus, Animals, Antibodies, Collagen Type IV, Fibroblasts, Hela Cells, Humans, Integrin alpha1, Integrin alpha1beta1, Mice, Mice, Knockout, Receptors, Adrenergic, beta-1, Receptors, Virus
DOI: 10.1016/j.virol.2005.03.015
ISSN: 0042-6822
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 01 Oct 2015 01:07
Last Modified: 02 Oct 2015 02:24

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