Current trends in the etiology and diagnosis of HPV-related head and neck cancers

Chai, Ryan C., Lambie, Duncan, Verma, Mukesh, & Punyadeera, Chamindie (2015) Current trends in the etiology and diagnosis of HPV-related head and neck cancers. Cancer Medicine, 4(4), pp. 596-607.

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Abstract

Human papilloma virus (HPV) infection is a major risk factor for a distinct subset of head and neck squamous cell carcinoma (HNSCC). The current review summarizes the epidemiology of HNSCC and the disease burden, the infectious cycle of HPV, the roles of viral oncoproteins, E6 and E7, and the downstream cellular events that lead to malignant transformation. Current techniques for the clinical diagnosis of HPV-associated HNSCC will also be discussed, that is, the detection of HPV DNA, RNA, and the HPV surrogate marker, p16 in tumor tissues, as well as HPV-specific antibodies in serum. Such methods do not allow for the early detection of HPV-associated HNSCC and most cases are at an advanced stage upon diagnosis. Novel noninvasive approaches using oral fluid, a clinically relevant biological fluid, allow for the detection of HPV and cellular alterations in infected cells, which may aid in the early detection and HPV-typing of HNSCC tumors. Noninvasive diagnostic methods will enable early detection and intervention, leading to a significant reduction in mortality and morbidity associated with HNSCC.

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ID Code: 87973
Item Type: Journal Article
Refereed: Yes
DOI: 10.1002/cam4.424
ISSN: 2045-7634
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Copyright Statement: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Deposited On: 02 Oct 2015 02:39
Last Modified: 11 Oct 2015 02:00

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