Genetics of ankylosing spondylitis and rheumatoid arthritis: Where are we at currently, and how do they compare?

Maksymowych, W.P. & Brown, M.A. (2009) Genetics of ankylosing spondylitis and rheumatoid arthritis: Where are we at currently, and how do they compare? Clinical and Experimental Rheumatology, 27(4SUP55), S20-S25.

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Both ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are common, highly heritable conditions, the pathogenesis of which are incompletely understood. Gene-mapping studies in both conditions have over the last couple of years made major breakthroughs in identifying the mechanisms by which these diseases occur. Considering RA, there is an over-representation of genes involved in TNF signalling and the NFκB pathway that have been shown to influence the disease risk. There is also considerable sharing of susceptibility genes between RA and other autoimmune diseases such as systemic lupus erythematosus, type 1 diabetes, autoimmune thyroid disease and celiac disease, with thus far little overlap with AS. In AS, genes involved in response to IL12/IL23, and in endoplasmic reticulum peptide presentation, have been identified, but a full genomewide association study has not yet been reported.

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ID Code: 87991
Item Type: Journal Article
Refereed: Yes
Additional Information: No text attached.
Keywords: Ankylosing spondylitis, Genetics, Rheumatoid arthritis, aminopeptidase, CD40 antigen, endoplasmic reticulum amiopeptidase 1, HLA B27 antigen, immunoglobulin enhancer binding protein, interleukin 12, interleukin 2, interleukin 21, interleukin 23, interleukin 23 receptor, peptidyl arginine deiminase 4, protein tyrosine phosphatase, protein tyrosine phosphatase 22, STAT4 protein, tumor necrosis factor, tumor necrosis factor receptor associated factor 1, tumor necrosis factor receptor associated factor 2, unclassified drug, allele, autoimmune thyroiditis, celiac disease, cell differentiation, chromosome 12q, endoplasmic reticulum, gene, gene mapping, genetic analysis, genetic association, genetic polymorphism, genetic susceptibility, HLA DRB1 gene, human, insulin dependent diabetes mellitus, peptidyl arginine deiminase 4 gene, priority journal, promoter region, protein tyrosine phosphatase 22 gene, review, signal transduction, single nucleotide polymorphism, systemic lupus erythematosus, T lymphocyte, Arthritis, Rheumatoid, Epitopes, Genetic Predisposition to Disease, Humans, Interleukin-12, Interleukin-23, Major Histocompatibility Complex, NF-kappa B, Spondylitis, Ankylosing, Tumor Necrosis Factor-alpha
ISSN: 0392-856X
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 01 Oct 2015 23:14
Last Modified: 22 Aug 2016 23:40

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