Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

Pimentel-Santos, F. M., Mourão, A. F., Ribeiro, C., Costa, J., Santos, H., Barcelos, A., Pinto, P., Godinho, F., Cruz, M., Vieira-Sousa, E., Santos, R. A., Rabiais, S., Félix, J., Fonseca, J. E., Guedes-Pinto, H., Brown, M.A., Branco, J. C., Mourão, A. F., De Matos, A. A., Ribeiro, C., Pimentel-Santos, F. M., Bravo Pimentão, J., Branco, J. C., Mateus, M., Nero, P., Araújo, P., Falcão, S., Pinto, T. L., Castelão, W., Vieira De Sousa, E., Caetano-Lopes, J., Fonseca, J. E., Silva, C., Simões, E., Madeira, H., Santos, H., Vaz Patto, J., Ferreira, J., Micaelo, M., Mediavilla, M. J., Sousa, M., Soares Branco, P., Godinho, F., Canas Da Silva, J., Garcês, S., Tavares, V., Ribeiro, A., Araújo, D., Costa, J. A., Costa, L., Afonso, M. C., Bogas, M., Alcino, S., Pinto, P., Cravo, A. R., Sequeira, G., Santos, R. A., Barcelos, A., Cunha, I., & Cruz, M. (2012) Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts. Clinical Rheumatology, 31(3), pp. 447-454.

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The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatient clinics, with AS defined according to the modified New York criteria. Demographic and clinical data were recorded. All radiographs were evaluated by two independent experienced readers. Centile charts for BASDAI, BASFI, BASMI and mSASSS were constructed for both genders, using generalized linear models and regression models with duration of disease as independent variable. A total of 369 patients (62.3% male, mean ± (SD) age 45.4 ± 13.2 years, mean ± (SD) disease duration 11.4 ± 10.5 years, 70.7% B27-positive) were included. Family history of AS in a first-degree relative was reported in 17.6% of the cases. Regarding clinical disease pattern, at the time of assessment 42.3% had axial disease, 2.4% peripheral disease, 40.9% mixed disease and 7.1% isolated enthesopatic disease. Anterior uveitis (33.6%) was the most common extra-articular manifestation. The centile charts suggest that females reported greater disease activity and more functional impairment than males but had lower BASMI and mSASSS scores. Data collected through this study provided a demographic and clinical profile of patients with AS in Portugal. The development of centile charts constitutes a useful tool to assess the change of disease pattern over time and in response to therapeutic interventions.

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ID Code: 87998
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: Ankylosing spondylitis, Charts, Epidemiology, corticosteroid, methotrexate, nonsteroid antiinflammatory agent, salazosulfapyridine, tumor necrosis factor alpha inhibitor, adult, aged, article, BASDAI questionnaire, BASFI questionnaire, Bath Ankylosing Spondylitis Metrological Index, clinical assessment tool, corticosteroid therapy, cross-sectional study, disease activity, disease course, disease duration, disease severity, enteritis, family history, female, heart disease, human, iridocyclitis, kidney disease, low back pain, lung disease, major clinical study, male, modified Stoke Ankylosing Spondylitis Severity Score, monotherapy, named inventories, questionnaires and rating scales, Portugal, priority journal, psoriasis, sex difference, Cross-Sectional Studies, Humans, Middle Aged, Questionnaires, Severity of Illness Index, Spondylitis, Ankylosing
DOI: 10.1007/s10067-011-1854-7
ISSN: 0770-3198
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Oct 2015 00:35
Last Modified: 25 Feb 2016 04:45

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