Does the microbiome play a causal role in spondyloarthritis?

Rosenbaum, James T., Lin, Phoebe, Asquith, Mark, Costello, Mary-Ellen, Kenna, Tony J., & Brown, Matthew A. (2014) Does the microbiome play a causal role in spondyloarthritis? Clinical Rheumatology, 33(6), pp. 763-767.

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The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged.

Impact and interest:

12 citations in Scopus
11 citations in Web of Science®
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ID Code: 87999
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: Inflammatory bowel disease, Microbiome, Spondyloarthritis, beta 2 microglobulin, HLA B27 antigen, ankylosing spondylitis, article, dendritic cell, disease association, genetic association, immune response gene, Lactobacillus rhamnosus, nonhuman, priority journal, animal, arthropathy, complication, human, immune system, microbiology, microflora, physiology, rat, spondylarthritis, transgenic animal, Animals, Animals, Genetically Modified, HLA-B27 Antigen, Humans, Inflammatory Bowel Diseases, Joint Diseases, Microbiota, Rats
DOI: 10.1007/s10067-014-2664-5
ISSN: 0770-3198
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Oct 2015 01:25
Last Modified: 22 Mar 2016 06:46

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