Genetic susceptibility to ankylosing spondylitis

Sims, A. M., Wordsworth, B. P., & Brown, M.A. (2004) Genetic susceptibility to ankylosing spondylitis. Current Molecular Medicine, 4(1), pp. 13-20.

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Ankylosing spondylitis is a highly heritable, common rheumatic condition, primarily affecting the axial skeleton. The association with HLA-B27 has been demonstrated worldwide, and evidence for a role of HLA-B27 in disease comes from linkage and association studies in humans, and transgenic animal models. However, twin studies indicate that HLA-B27 contributes only 16% of the total genetic risk for disease. Furthermore, there is compelling evidence that non-B27 genes, both within and outwith the major histocompatability complex, are involved in disease aetiology. In this post-genomic era we have the tools to help elicit the genetic basis of disease. This review describes methods for genetic investigation of ankylosing spondylitis, and summarises the status of current research in this exciting area.

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ID Code: 88002
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: beta 2 microglobulin, cytokine, debrisoquine 4 hydroxylase, HLA antigen class 1, HLA B27 antigen, HLA B60 antigen, HLA DR antigen, immunoglobulin enhancer binding protein, interleukin 1, interleukin 10, interleukin 6, major histocompatibility antigen class 2, T lymphocyte receptor, transforming growth factor beta1, tumor necrosis factor, ankylosing spondylitis, cytokine release, cytotoxic T lymphocyte, gene mapping, genetic association, genetic epidemiology, genetic linkage, genetic risk, genetic susceptibility, human, major histocompatibility complex, molecular mimicry, nonhuman, pathogenesis, retrospective study, review, single nucleotide polymorphism, X chromosome, Animals, Chromosome Mapping, Cytokines, Disease Susceptibility, Gene Expression, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, HLA-B27 Antigen, Humans, Linkage (Genetics), Mice, Spondylitis, Ankylosing, Animalia
DOI: 10.2174/1566524043479284
ISSN: 1566-5240
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Oct 2015 01:35
Last Modified: 18 Oct 2015 22:56

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