Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis

Brown, M.A., Crane, A. M., & Wordsworth, B. P. (2002) Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis. Current Opinion in Rheumatology, 14(4), pp. 354-360.

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While twin studies have previously demonstrated high heritability of susceptibility to ankylosing spondylitis (AS), it is only recently that the involvement of genetic factors in determining the severity of the disease has been demonstrated. The genes involved in determining the rate of ankylosis in AS are likely to be different from those involved in the underlying immunologic events, and represent important potential targets for treatment of AS. This article will describe the progress that has been made in the genetic epidemiology of AS, and in identifying the genes involved.

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18 citations in Scopus
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9 citations in Web of Science®

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ID Code: 88006
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: HLA B27 antigen, HLA B60 antigen, HLA DR antigen, tumor necrosis factor alpha, allele, ankylosing spondylitis, disease severity, enteritis, gene, gene linkage disequilibrium, gene mapping, genetic epidemiology, genetic linkage, genetic polymorphism, genetic susceptibility, heritability, human, major histocompatibility complex, priority journal, review, chromosome map, epidemiology, gene expression, genetic predisposition, genetics, pathophysiology, twins, Chromosome Mapping, Diseases in Twins, Epidemiology, Molecular, Genetic Predisposition to Disease, Spondylitis, Ankylosing, Support, Non-U.S. Gov't, Humans
DOI: 10.1097/00002281-200207000-00004
ISSN: 1040-8711
Divisions: Current > Schools > School of Biomedical Sciences
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Oct 2015 01:57
Last Modified: 18 Oct 2015 22:57

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