The ASAS criteria for axial spondyloarthritis: Strengths, weaknesses, and proposals for a way forward

van der Linden, S., Akkoc, N., Brown, M.A., Robinson, P.C., & Khan, M.A. (2015) The ASAS criteria for axial spondyloarthritis: Strengths, weaknesses, and proposals for a way forward. Current Rheumatology Reports, 17(9).

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Classification criteria should facilitate selection of similar patients for clinical and epidemiologic studies, therapeutic trials, and research on etiopathogenesis to enable comparison of results across studies from different centers. We critically appraise the validity and performance of the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA). It is still debatable whether all patients fulfilling these criteria should be considered as having true axSpA. Patients with radiographically evident disease by the ASAS criteria are not necessarily identical with ankylosing spondylitis (AS) as classified by the modified New York criteria. The complex multi-arm selection design of the ASAS criteria induces considerable heterogeneity among patients so classified, and applying them in settings with a low prevalence of axial spondyloarthritis (SpA) greatly increases the proportion of subjects falsely classified as suffering from axial SpA. One of the unmet needs in non-radiographic form of axial SpA is to have reliable markers that can identify individuals at risk for progression to AS and thereby facilitate early intervention trials designed to prevent such progression. We suggest needed improvements of the ASAS criteria for axSpA, as all criteria sets should be regarded as dynamic concepts open to modifications or updates as our knowledge advances.

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8 citations in Web of Science®
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ID Code: 88009
Item Type: Journal Article
Refereed: Yes
Additional Information: No file attached.
Keywords: Ankylosing spondylitis (AS), ASAS classification criteria, Assessment of SpondyloArthritis international Society (ASAS), Axial spondyloarthritis (axSpA), Spondyloarthritis (SpA), adalimumab, calgranulin, CD74 antigen, certolizumab pegol, dickkopf 1 protein, etanercept, golimumab, HLA B27 antigen, infliximab, sclerostin, stromelysin, vasculotropin, vimentin, ankylosing spondylitis, Assessment of SpondyloArthritis International Society criteria, axial spondylarthritis, construct validity, content validity, criterion related validity, disease classification, face validity, false positive result, gene, genetic variability, genomics, human, MHC gene, non MHC gene, nuclear magnetic resonance imaging, predictive value, proteomics, Review, sensitivity and specificity, spondylarthritis, treatment response
DOI: 10.1007/s11926-015-0535-y
ISSN: 1523-3774
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Oct 2015 00:29
Last Modified: 25 Jun 2017 19:01

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