Trans-scale granular modelling of cytoskeleton: A mini-review

Li, Tong, Yarlagadda, Prasad K., Oloyede, Adekunle, Thibbotuwawa, Namal, & Gu, YuanTong (2015) Trans-scale granular modelling of cytoskeleton: A mini-review. Molecular & Cellular Biomechanics, 12(1), pp. 17-35.

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Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated dynamic cellular processes. Fortunately, multiscale modelling provides a powerful simulation tool that can be used to study the mechanical properties of these soft hierarchical, biological systems. This paper reviews recent developments in hierarchical multiscale modeling technique that aimed at understanding cytoskeleton mechanics. Discussions are expanded with respects to cytoskeletal components including: intermediate filaments, microtubules and microfilament networks. The mechanical performance of difference cytoskeleton components are discussed with respect to their structural and material properties. Explicit granular simulation methods are adopted with different coarse-grained strategies for these cytoskeleton components and the simulation details are introduced in this review.

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ID Code: 88026
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Cytoskeleton, Intermediate filament, Microtubules, Microfilament network, Mechanics, Multiscale
DOI: 10.3970/mcb.2015.012.017
ISSN: 1556-5300
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Australian and New Zealand Standard Research Classification
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 06 Oct 2015 01:49
Last Modified: 06 Oct 2015 23:07

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